Chronic idiopathic constipation (CIC) and Irritable Bowel Syndrome Constipation (IBS-C) are some common conditions causing constipation in a wide range of the population. The difference between the two is the presence of abdominal pain as a predominant symptom in the latter. Although the exact cause is unknown, the possible cause for constipation is the lack of fluid in the lumen of the intestines due to various factors. To solve this problem, Plecanatide increases the cGMP activity, which in turn increases the fluid levels, normalizing the bowel movements, which his has been smoothly demonstrated in the animations. Plecanatide acts on the GCC-C receptors in the epithelium of the small intestine, stimulating cGMP synthesis. This activates Chloride channel openings, secreting chloride into the intestinal lumen. Water follows the chloride into the lumen. The increased fluid levels in the lumen soften the stool and help increase bowel movements.